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第六届超高压生物科学与技术国际会议闭幕

 

    第六届超高压生物科学与技术国际会议于2010年8月28日至9月1日在德国慕尼黑北部的弗赖辛召开。来自德国、法国、英国、西班牙、美国、加拿大、比利时、葡萄牙、苏格兰、匈牙利、波兰、科索沃、立陶宛、亚美尼亚、日本、印度、巴西、新西兰、中国等世界各地100多名从事超高压生物科学与技术的专家与学者聚集一堂,对“高压敏感分子的机制、高分子与高压加工、小分子与高压加工、高压敏感有机系统、深海生物、高压加工食品微生物学、高压加工对人类的影响、高压技术、高压技术分析”等学术问题发表论文并进行了热烈讨论。

    会议由德国慕尼黑理工大学Rudy F. Vogel教授主持,日本近畿大学的Kazuyuki Akasaka教授做了主题报告“High Pressure NMR Study of Proteins - Seeking Roots for Function,Evolution, Disease and Food Applications”。除了发表论文外,会场还有几十块展板,发表了论文摘要。

    我国首次出席这样的国际会议,郑捷代表天津科技大学食品学院刘安军院长、天津华泰森淼公司总工程师贾培起等五位参加研究的人员发表了论文“Super high pressure effects on properties and ultrastructure of beef(高压对牛肉蒸煮损失和组织结构的影响研究)”受到与会者的关注。

    会议决定第七届超高压生物科学与技术国际会议与2012年在日本举行,会议主持人为Kazuyuki Akasaka教授。

会场外景

 

会议主会场

 

郑捷老师做报告

 

与会议主席Rudy(中)合影,左:贾培起,右:郑捷

 

Lecture program
Saturday, August 28, 2010
From 14:00 Reception open - Poster mounting
17:00 Opening / Welcome, Rudi F. Vogel
Introductory Lecture
Chair: Rudi F. Vogel
17:15 High Pressure NMR Study of Proteins - Seeking Roots for Function,
Evolution, Disease and Food Applications Kazuyuki Akasaka, Kinki
University, Kinokawa, Japan
LI1
19:00 Welcome reception
Sunday, August 29, 2010
CHAPTER 1: High pressure sensitive molecular mechanisms
Session 1: Macromolecules and HHP
Chair: Lazlo Smeller and Phil Oger
08:30 KEYNOTE LECTURE: The physical basis for pressure effects on
protein structure and stability. Catherine Royer. INSERM Centre de
Biochimie Structurale, Montpellier, France
L101
09:10 Origins of Pressure-induced Protein Transitions. Tigran V. Chalikian,
Leslie Dan Faculty of Pharmacy, Toronto, Canada
L102
09:30 SPOTLIGHT LECTURE: HP effects on amyloidogenic proteins. Jerson
Silva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
L103
10:00 Break
10:30 SPOTLIGHT LECTURE: Revealing protein flexibility in spin labelled
proteins using high pressure EPR. Wayne L. Hubbell, University of
California, Los Angeles, USA
L104
11:00 Protein-protein interactions - the effects of cosolvents, crowding and
pressure, Roland Winter, Technische Universität Dortmund, Germany
L105
11:30 Effects of pressure on the solubility and thermodynamic parameters
of tetragonal lysozyme crystals Takahisa Fujiwara, The University of
Tokushima, Japan.
L106
11:50 TET3 protease from Pyrococcus horikoshii reveals astonishing
properties of high pressure and temperature resistance
Eva Rosenbaum, Laboratori de Llum de Sincrotró, c/o ESRF, France
L107
12:10 Lunch
Session 1 continued
Chair: Catherine Royer and Tigran Chalikian
13:30 Adaptation of cytochrome P450 from a piezophilic bacteria to high
hydrostatic pressures provides a clue to the mechanisms of
substrate-induced transitions. Elena Sineva and Dmitri R Davydov,
University of California, San Diego, USA
L108
13:50 The Volumes of Ligand Binding to Hsp90 by High Pressure
Denaturation, Zigmantas Toleikis, Piotras Cimmperman, and Daumantas
Matulis, Institute of Biotechnology, Vilnius, Lithuania
L109
14:10 Discrete States of Casein Micelles probed by High Pressure Light
Scattering, R. Gebhardt, U. Kulozik and W. Doster, Technische Universität
München, Germany
L110
14:30 Use of biological tools to investigate the effect of high-pressure
treatments on food protein components. Amal Benzaria, Stéphane
Marchal, Malika René-Trouillefou, Bertrand Caporiccio, Reinhard Lange
and Eliane Dumay, University of Montpellier, France
L111
14:50 Non-enzymatic modifications of proteins under high pressure
treatment, Uwe Schwarzenbolz, Thomas Henle, Technsiche Universität
Dresden, Germany
L112
15:10 Break and poster viewing
16:10 Packing state in bilayer membranes of diacylphosphatidylcholines
with varying acyl chain lengths under high pressure
Hitoshi Matsuki, Masaki Goto, Nobutake Tamai and Shoji Kaneshina,
University of Tokushima, Japan
L113
16:30 Rheological Investigations of Viscoelastic Substances under High
Pressure, L. Kulisiewicz, A. Delgado, C. Rauh, M. Nagel, A. Wierschem,
University Erlangen-Nürnberg, Germany.
L114
Session 2: Small Molecules and HHP
Chair: Roland Winter
16:50 Gelatinization kinetic of waxy starches under pressure according to
ionic strength, Simonin H., Guyon C., Marzouki S., de Lamballerie M., Le
Bail A., GEPEA, ONIRIS site Géraudière, Nantes, France
L201
17:10 High-Pressure: a tool to increase the production of novel glycosides
Helder Vila-Real, António J. Alfaia, António R. Calado, Maria H.L. Ribeiro,
University of Lisbon, Portugal
L202
17:30 High-Pressure enhanced activity and stability of a-L-rhamnosidase
and b-D-glucosidase activities expressed by naringinase immobilized
onto sol-gel@IL matrices, Helder Vila-Real, António J. Alfaia, Pedro
Góis, António R. Calado, Maria H.L. Ribeiro, University of Lisbon, Portugal
L203
18:30 Dinner
20:00 Visit to the Freising Cathedral – optional guided tour
Monday, August 30, 2010
CHAPTER 2: High pressure sensitive organismic systems
Session 3: Deep sea biology
Chair: Fumiyoshi Abe and Abram Aertsen
08:30 KEYNOTE LECTURE: Microbial activity in deep sea sediments. Phil M.
Oger Université de Lyon, Ecole Normale Supérieure de Lyon, France
L301
09:10 Multiple sequence analysis reveals high diversity of uncultured fungi
in the deep-sea sediments of the Central Indian Basin. Singh P. and
Raghukumar C. National Institute of Oceanography, Goa, India
L302
09:30 Culturable Yeast Diversity from Deep-sea Waters of the Equatorial
Indian Ocean, Samir Damare, Varada Damare, Pankaj Verma,
Chandralata Raghukumar. National Institute of Oceanography, Goa, India
L303
09:50 Pyrococcus yayanosii nov., the first strict piezophilic
hyperthermophilic archaeon isolated from a deep-sea hydrothermal
vent, Mohamed. Jebbar, Université de Bretagne Occidentale, Plouzané,
France
L304
10:10 Break and poster viewing
11:10 Learning About High Pressure-Adapted Deep-Sea Microbes One Cell
at a Time, Douglas H. Bartlett, Scripps Institution of Oceanography,
University of California, San Diego, La Jolla, USA
L305
11:40 High-throughput screening of the Keio Collection identifies novel
genes required for growth of Escherichia coli at pressure
S. Lucas Black, F. Bruce Ward and Rosalind J. Allen, University of
Edinburgh, Edinburgh
L306
12:00 Investigation of useful piezophilic microorganisms from deep-sea
environments, Chiaki Kato, Takayoshi Sekiguchi, Makiko Enoki, Haruyuki
Kanehiro, Fuyu Ito and Shigeru Yamanaka, Japan Agency for Marine-
Earth Science and Technology, Japan
L307
12:20 Lunch
Session 4: HHP (food) microbiology
Chair: Douglas Bartlett and Patricia Fernandes
13:40 SPOTLIGHT LECTURE: Dynamics of microbial membranes under
high pressure: a study using time-resolved fluorescence anisotropy
measurement, Fumiyoshi Abe, Japan Agency for Marine-Earth Science
and Technology, Japan
L401
14:00 The emergence, extent and stability of high pressure resistance in
mesophilic bacteria. Dietrich Vanlint, Nele Rutten, Rachael Hazael,
Edward Bailey, Filip Meersman, Paul F. McMillan, Chris W. Michiels,
Abram Aertsen. Katholieke Universiteit Leuven, Belgium.
L402
14:20 Effect of High Hydrostatic Pressure on Fermentation Yeasts, Melba P.
Ortega, Lei Zhong, Hiromi Baum, Xiaoye Gu, Mariko Kawamura, Atsushi
Kobayashi, Akira Yamazaki, and Kazutaka Yamamoto, National Food
Research Institute, NARO, Japan
L403
14:40 Comparative proteomic analyses of Saccharomyces cerevisiae under
high hydrostatic pressure, Carolina D. V. Schuwartz, A. Alberto R.
Fernandes, Patricia M. B. Fernandes, Universidade Federal do Espírito
Santo, Brasil
L404
15:00 The role of proteasome for the response after sub-lethal high
pressure treatment in yeast Saccharomyces cerevisae, Hitoshi
Iwahashi, Tetsuji Higashi, Randeep Rakwal, Junko Shibato, Shin-nichi
Wakida, National Institute of Advanced Industrial Science and Technology,
Japan
L405
15:20 Analyses of global gene expression pattern of distillery yeast strain
submitted to high hydrostatic pressure treatment. Bravim, F., Lippman,
S. , Broach, J.R., Fernandes, A.A.R., Fernandes, P.M.B. Universidade
Federal do Espírito Santo, Brasil
L406
15:40 HP-inactivation kinetics and phenotypic properties of barosensitive
yeast mutants obtained by UV mutagenesis
Toru Shigematsu, Kazuki Nomura, Yusuke Nasuhara, Kenta Ikarashi, Gen
Nagai, Masao Hirayama, Mayumi Hayashi, Shigeaki Ueno, Tomoyuki Fujii,
Niigata University of Pharmacy and Applied Life Sciences, Japan
L407
16:00 Break
Session 4 continued: HHP (food) microbiology
Chair: Chiaki Kato
16:30 Behaviour of Clostridium botulinum Type E endospores in high
pressure treatments in model systems versus real foods. Christian
Lenz, Rita Paralta, Rudi F. Vogel, Technische Universit?t München,
Germany
L408
16:50 High-pressure assisted thermal inactivation of Clostridium spp.
endospores treated with nisin and reutericyclin. Simmon Hofstetter,
Michael G. G?nzle, and Lynn M. McMullen, University of Alberta,
Edmonton, AB, Canada
L409
17:10 Comparison of fluorescence based methods for rapid detection of the
pressure induced germination of bacterial spores, Daniel Baier, Kai
Reineke, Isabel Doehner, Alexander Mathys, Dietrich Knorr, Technische
Universit?t Berlin, Germany
L410
17:30 Pressure induced germination of Bacillus subtilis spores – A
mechanistic study, Kai Reineke, Isabel D?hner, Alexander Mathys,
Dietrich Knorr, Technische Universit?t Berlin, Germany
L411
18:30 Dinner
20:00 Beer and poster session
Tuesday, August 31, 2010
Session 5: HHP effects on humans
Chair: Roland Meyer-Pittroff
08:30 KEYNOTE LECTURE: Trends in molecular and cellular models of High
Pressure Neurological Syndrome (HPNS), Stephen Daniels, PETIC,
School of Medicine, Cardiff University, UK.
L501
09:10 High Hydrostatic Pressure Induces Protein Unfolding and
Aggregation in Mammalian Cells Resulting in Terminal ER-stress
Response, Frey, B., Weiss, E.M., Schl?tzer-Schrehardt, Meyer-Pittroff, R.,
Ebel N., Schlücker E., Fietkau R., Voll, R.E., Herrmann, M., Meister, S. and
Gaipl, U.S. Dpartment of Radiation Oncology, University of Erlangen-
Nürnberg, Germany
L502
09:30 High Hydrostatic Pressure Inactivation of Tumor Cells by Preserving
their Immunogenicity –Generation of a Whole Cell Based Tumor
Vaccine, Weiss E. M., Janko C., Meister S., Ebel N., Schlücker E., Meyer-
Pittroff R., Fietkau R., Herrmann M., Gaipl U.S., Frey B., Department of
Radiation Oncology, Friedrich-Alexander-University of Erlangen-Nürnberg,
Germany
L503
09:50 Break
CHAPTER 3: High pressure technologies
Session 6: Productive HHP (food) technologies
Chair: Horst Christian Langowski
10:20 KEYNOTE LECTURE: Challenges of high pressure food processes,
Volker Heinz, Deutsches Institut für Lebensmitteltechnik, Quakenbrück,
Germany
L601
11:00 Process optimization and control strategies for industrial and
laboratory high pressure processes, Cornelia Rauh, Antonio Delgado,
Lehrstuhl für Str?mungsmechanik, Friedrich-Alexander Universit?t
Erlangen-Nürnberg, Germany
L602
11:20 Pressure Assisted Thermal Sterilization of Soup, Kidane Shibeshi and
Mohammed Farid, Department of Chemical and Materials Engineering, the
University of Auckland, New Zealand
L603
11:40 Super high pressure effects on properties and ultrastructure of beef,
Jie Zheng. Key Laboratory of Food Nutrition and Safety,Tianjin University
of Science & Technology, China
L604
12:00 Lunch
13:00 Excursion
Wednesday, September 1, 2010
Session 6: continued
Chair: Helene Simonin
08:30 Pressure and temperature stability of the main apple allergen Mal d1,
Judit Somkuti, Milan Houska, László Smeller, Dept. Biophysics and
Radiation Biology, Semmelweis University, Budapest, Hungary
L605
08:50 Effect of k-casein hydrolysis on the reassociation behaviour of
pressure decomposed casein micelles
Martin Heinrich, Ronald Gebhardt, Ulrich Kulozik, Lehrstuhl für
Lebensmittelverfahrenstechnik und Molkereitechnologie, Technische
Universit?t München, Germany
L606
09:10 High-pressure assisted encapsulation of vitamin D2 in re-assembled
casein micelles, Orquídea Menéndez-Aguirre, Wolfgang Stuetz, Tilman
Grune, Anne Kessler, Jochen Weiss, J?rg Hinrichs, Animal Foodstuff
Technology, Universit?t Hohenheim, Germany
L607
09:30 Nonenzymatic Glycation and Deamidation of Food Proteins at High
Hydrostatic Pressure, Markus Brunnbauer, Peter Koehler, German
Research Centre for Food Chemistry, Germany
L608
09:50 Normal and Waxy Corn Starches Treated with High Hydrostatic
Pressure, Kazutaka Yamamoto, Ken Fukami, Tamao Hatta, Hajime
Taniguchi, and Kiyoshi Kawai, National Food Research Institute, NARO,
Japan
L609
10:10 Break
Session 6: continued
Chair: Kazutaka Yamamoto
10:40 High pressure-induced structural effects in plastic packaging, Tobias
Richter, Verena Jost, Julia Sterr and Horst-Christian Langowski, Lehrstuhl
fuer Lebensmittelverpackungstechnik, Technische Universit?t München,
Germany
L610
11:00 PH-sensitive Coatings for In-Situ Optical Measurement During High-
Pressure Treatment of Food, M. Nagel, A. Jurchela, C. Rauh, A.
Wierschem and A. Delgado, Institute of fluid mechanics, Friedrich-
Alexander University of Erlangen-Nuremberg, Germany
L611
Session 7: Analytical HHP technologies
11:20 A multi-purpose modular system for high-resolution microscopy at
high hydrostatic pressure
Hugh Vass, S. Lucas Black, Eva Herzig, Paul Clegg, F. Bruce Ward and
Rosalind J. Allen, SUPA School of Physics and Astronomy, University of
Edinburgh, UK
L701
11:40 Farewell

弗赖辛介绍
   弗赖辛(Freising)是德国巴伐利亚州弗赖辛县的首府,人口为48,400。城市位于慕尼黑以北的伊萨尔河畔,与慕尼黑国际机场相邻。来往机场的人都可以看到弗赖辛的两座著名山峰---一为主教城堡坐落的教堂山,一为世界上最古老的酿酒坊坐落的魏恩施蒂芬山。
   历史
   虽然考古发现认为弗赖辛从铜器时代就开始有人定居了,但是并没有发现相关的证据。有据可查的历史始于8世纪,弗赖辛教区的先驱---圣徒Corbinian居住的神殿早大724年就已存在了。根据主教Arbeo整理的Corbinian的传记所记载,Corbinian是由一头熊驮着他的行李翻越阿尔卑斯山的,如今,驮着行李的熊的图案已成为弗赖辛市徽的一部分。虽然教区的教座已在1821年就搬到慕尼黑去了,但直到今天弗赖辛仍然是教区行政部门所在地。
   主教Arbeo于764年-783年在修道院里建造了图书馆和缮写室,于是弗赖辛开始逐渐成为宗教中心。
   996年,费赖辛从奥托三世获得了城市权利。但是,在1150年左右慕尼黑建城之后,弗赖辛就逐渐丧失了其重要的经济地位。
   文化意义
   弗赖辛是巴伐利亚州最古老的人类定居点,在中世纪早期成为巴伐利亚主要的宗教中心,现在也仍是重要的主教教区中心。一些重要的历史文献就是在900年至1200年此地的修道院编写的。

 

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